Total safety by design: Increased safety and operability of supply chain of inland terminals for containers with dangerous goods

[EN] In recent years, there has been a considerable increase in the international transport of containers with dangerous goods, increasing the risk of seaports and surrounding cities together with the introduction of inherent environmental and security disaster risks. Therefore, there is an increasing interest in seaports that are more socially inclusive, addressing the storage of containers of hazardous goods to safe inland terminals. An appropriate design of inland terminals for containers with dangerous goods (ITDGs) may contribute to the achievement of a sustainable development and the minimization of risks, avoiding disasters such as Tianjin. The objective of this study was the analysis of the criteria used for the design of safe, secure, cost efficient and greener ITDGs by applying the multicriteria decision theory AHP (analytic hierarchy process). Criteria regarding safety and security, environmental care, productivity and information and communication technologies (ICT) have been considered simultaneously into a total performance management system. (C) 2016 Elsevier Ltd. All rights reserved.Public funding entity: Generalitat Valenciana.Molero Prieto, GD.; Santarremigia Rosaleny, FE.; Aragonés-Beltrán, P.; Pastor-Ferrando, J. (2017). Total safety by design: Increased safety and operability of supply chain of inland terminals for containers with dangerous goods. Safety Science. 100(B):168-182. https://doi.org/10.1016/j.ssci.2016.10.007S168182100

Las lámparas de vidrio y portamechas localizados en contextos cristianos (siglos V-VII): los casos de Barcelona (Barcino) y Terrassa (Egara)

In this article, we present some archaeological testimonies of glass lamps and wick holders located in contexts of the 5th-7th centuries, in the episcopal group of Barcelona and in that of Egara (Terrassa). Likewise, the meaning that lamps and lighting had in cult buildings, their status and consideration through written texts and the theological symbolism of light are addressed.En este artículo presentamos algunos testimonios arqueológicos de lámparas de vidrio y portamechas localizados en contextos de los siglos V-VII, en el grupo episcopal de Barcelona y en el de Egara (Terrassa). Asimismo, se aborda el significado que tenían las lámparas y la iluminación en los edificios de culto, su estatus y consideración a través de los textos escritos y el simbolismo teológico de la luz

Electrocución en aves salvajes protegidas

En este trabajo de fin de grado se va a exponer la situación que sucede desde años atrás en España, y más concretamente el caso de Aragón, sobre la electrocución de aves salvajes en los tendidos eléctricos sin aislamiento o con medidas de aislamiento antielectrocución ineficientes, lo cual es una de las principales causas de mortandad no natural de estas especies, ya que muchas de ellas utilizan los tendidos como posadero. Entre estos ejemplares se encuentran especies protegidas y amenazadas, por lo que es muy importante corregir estos tendidos. Así pues se van a describir ciertas medidas y normas de carácter técnico de aplicación a las líneas eléctricas, para evitar que se electrocuten y se agrave todavía más su situación poblacional, además de explicar el tratamiento que se debe aplicar a las aves en estos casos.<br /

Bioactive compounds derived from the yeast metabolism of aromatic amino acids during alcoholic fermentation

Metabolites resulting from nitrogen metabolism in yeast are currently found in some fermented beverages such as wine and beer. Their study has recently attracted the attention of researchers. Some metabolites derived from aromatic amino acids are bioactive compounds that can behave as hormones or even mimic their role in humans and may also act as regulators in yeast. Although the metabolic pathways for their formation are well known, the physiological significance is still far from being understood. The understanding of this relevance will be a key element in managing the production of these compounds under controlled conditions, to offer fermented food with specific enrichment in these compounds or even to use the yeast as nutritional complement

Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis

Immunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT). A positive correlation between CRT exposure or total expression and improved anticancer immunosurveillance has been found in certain cancers, usually accompanied by favorable patient prognosis. In the present study, we sought to evaluate CRT levels in the plasma membrane of CD38+ bone marrow mononuclear cells (BMMCs) isolated from 71 patients with varying degrees of multiple myeloma (MM) disease and examine the possible relationship between basal CRT exposure and the bone marrow immune microenvironment, as well as its connection with different clinical markers. Data show that increased levels of cell surface-CRT were associated with more aggressive clinical features and with worse clinical prognosis in MM. High CRT expression in MM cells was associated with increased infiltration of NK cells, CD8+ T lymphocytes and dendritic cells (DC), indicative of an active anti-tumoral immune response, but also with a significantly higher presence of immunosuppressive Treg cells and increased expression of PD-L1 in myeloma cells

Hypertension is related to the degradation of dietary frying oils

[Background]: The family kitchen resembles an uncontrolled laboratory experiment, and some discrepancies in the relation between the risk of hypertension and dietary fat may be partly due to the manipulation to which the fats were subjected. [Objective]: We investigated whether deterioration in the quality of the cooking oils in the family household contributes to the risk of high blood pressure. [Design]: The study was cross-sectional. Anthropometric measurements were obtained for 1226 persons aged 18–65 y who were selected randomly from the municipal census of Pizarra, Spain. An oral-glucose-tolerance test was given to 1020 of these persons. Samples of the cooking oil being used were taken from the kitchens of a random subset of 538 persons. The concentrations of polar compounds and polymers were used as markers of the deterioration of the oils. The strength of association between variables was measured by calculating the odds ratio from logistic models. [Results]: Hypertension was strongly associated with obesity and was influenced by sex, diabetes, and age. The presence of excess polar compounds in the cooking oil and the use of sunflower oil were related to the risk of hypertension, whereas the concentration of monounsaturated fatty acids in the serum phospholipids was negatively related to this risk. These associations remained after inclusion in the models of age, sex, obesity, and the presence of carbohydrate metabolism disorder. [Conclusions]: The risk of hypertension is positively and independently associated with the intake of cooking oil polar compounds and inversely related to blood concentrations of monounsaturated fatty acids

Guia clínica per a l'atenció de les persones amb símptomes persistents de COVID-19

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV-2; Símptomes persistents; Guia clínicaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV-2; Síntomas persistentes; Guía clínicaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV-2; Persistent symptoms; Clinical guideLes persones amb símptomes persistents de COVID-19 són majoritàriament dones d’edat mitjana i representen un problema de salut emergent, ja que aquests símptomes poden ocasionar un fort impacte sobre la qualitat de vida. Aquesta circumstància també pot afectar persones joves sense cap malaltia prèvia. El seu pronòstic a llarg termini és desconegut. Els símptomes persistents són molt variats i poden ser fluctuants i agrupar-se en una mateixa persona. Per a la gran majoria de persones amb símptomes de COVID-19 persistent ha de prevaldre l’atenció centrada exclusivament en l’equip d’atenció primària (AP), amb un abordatge integral i amb visió biopsicosocial, i amb el suport de professionals com els de salut mental, els dels serveis de rehabilitació i els de treball social quan sigui necessari. L’observació i l’abordatge de la simptomatologia persistent en aquestes persones representen una oportunitat per generar coneixement des de l’AP, juntament amb les persones afectades. La manca de símptomes patognomònics i/o proves específiques dificulta el diagnòstic i obliga a descartar altres malalties que poden tenir presentacions similars, sovint per arribar a un diagnòstic per exclusió. La manca d’un tractament específic fa que l’acompanyament d’aquestes persones tingui com a objectiu alleugerir el seu malestar i facilitar la seva reincorporació a l’activitat habitual.Las personas con síntomas persistentes de COVID-19 son mayoritariamente mujeres de edad media y representan un problema de salud emergente, ya que estos síntomas pueden ocasionar un fuerte impacto sobre la calidad de vida. Esta circunstancia también puede afectar a personas jóvenes sin enfermedad previa. Su pronóstico a largo plazo es desconocido. Los síntomas persistentes son muy variados y pueden ser fluctuantes y agruparse en una misma persona. Para la gran mayoría de personas con síntomas de COVID-19 persistente debe prevalecer la atención centrada exclusivamente en el equipo de atención primaria (AP), con un abordaje integral y con visión biopsicosocial, y con el apoyo de profesionales como los de salud mental, los de los servicios de rehabilitación y los de trabajo social cuando sea necesario. La observación y el abordaje de la sintomatología persistente en estas personas representan una oportunidad para generar conocimiento desde la AP, junto con las personas afectadas. La falta de síntomas patognomónicos y / o pruebas específicas dificulta el diagnóstico y obliga a descartar otras enfermedades que pueden tener presentaciones similares, a menudo para llegar a un diagnóstico por exclusión. La falta de un tratamiento específico hace que el acompañamiento de estas personas tenga como objetivo aliviar su malestar y facilitar su reincorporación a la actividad habitual.People with persistent symptoms of COVID-19 are mostly middle-aged women and represent an emerging health problem, as these symptoms can have a strong impact on quality of life. This circumstance can also affect young people without any previous illness. Its long-term prognosis is unknown. Persistent symptoms are very varied and can be fluctuating and grouped into a single person. For the vast majority of people with symptoms of persistent COVID-19, care focused exclusively on the primary care team (PA) should prevail, with a comprehensive approach and a biopsychosocial vision, and with the support of professionals such as those of mental health, those of rehabilitation services and those of social work when necessary. Observing and addressing the persistent symptomatology in these people represents an opportunity to generate knowledge from the PA, along with those affected. The lack of pathognomonic symptoms and / or specific tests makes diagnosis difficult and forces us to rule out other diseases that may have similar presentations, often to arrive at a diagnosis by exclusion. The lack of specific treatment means that the support of these people aims to alleviate their discomfort and facilitate their reintegration into the usual activity

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P <.05) and less refractoriness (4.5% vs 14.1%; P <.05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P <.05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P <.001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P < .05) and less refractoriness (4.5% vs 14.1%; P < .05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P < .05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P < .001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX

TFG 2013/2014

Amb aquesta publicació, EINA, Centre universitari de Disseny i Art adscrit a la Universitat Autònoma de Barcelona, dóna a conèixer el recull dels Treballs de Fi de Grau presentats durant el curs 2013-2014. Voldríem que un recull com aquest donés una idea més precisa de la tasca que es realitza a EINA per tal de formar nous dissenyadors amb capacitat de respondre professionalment i intel·lectualment a les necessitats i exigències de la nostra societat. El treball formatiu s’orienta a oferir resultats que responguin tant a paràmetres de rigor acadèmic i capacitat d’anàlisi del context com a l’experimentació i la creació de nous llenguatges, tot fomentant el potencial innovador del disseny.Con esta publicación, EINA, Centro universitario de diseño y arte adscrito a la Universidad Autónoma de Barcelona, da a conocer la recopilación de los Trabajos de Fin de Grado presentados durante el curso 2013-2014. Querríamos que una recopilación como ésta diera una idea más precisa del trabajo que se realiza en EINA para formar nuevos diseñadores con capacidad de responder profesional e intelectualmente a las necesidades y exigencias de nuestra sociedad. El trabajo formativo se orienta a ofrecer resultados que respondan tanto a parámetros de rigor académico y capacidad de análisis, como a la experimentación y la creación de nuevos lenguajes, al tiempo que se fomenta el potencial innovador del diseño.With this publication, EINA, University School of Design and Art, affiliated to the Autonomous University of Barcelona, brings to the public eye the Final Degree Projects presented during the 2013-2014 academic year. Our hope is that this volume might offer a more precise idea of the task performed by EINA in training new designers, able to speak both professionally and intellectually to the needs and demands of our society. The educational task is oriented towards results that might respond to the parameters of academic rigour and the capacity for contextual analysis, as well as to considerations of experimentation and the creation of new languages, all the while reinforcing design’s innovative potential